Accurate Breast Screening for Early-Stage Cancer Detection: Introducing Koning Vera Breast CT (KBCT)!

Breast Cancer Analysis of Circulating Tumor Cells from Traditional 2D Mammograms!

Breast cancer is a common malignancy that affects countless women worldwide. While traditional 2D mammography has long been the gold standard for breast cancer screening in asymptomatic females, it does have its limitations.

Traditional 2D Mammograms can expose women to radiation, may have lower specificity in differentiating benign conditions from malignancy, and can be less sensitive to invasive carcinomas. Additionally, 2D mammography is not always compatible with dense breast tissue, which can further complicate accurate detection.

Koning Vera Breast CT (KBCT) – a game-changer for early detection of breast cancer!

Koning Vera Breast CT (KBCT) is a state-of-the-art technology that concentrates on detecting and analysing circulating tumour cells (CTCs) in the blood. CTCs are malignant cells that have broken away from the primary tumour and entered the bloodstream while still being intact. They contain valuable information about the "parent tumour" and offer unique benefits over other analytes, such as Nucleic acid fragments or serum antigens.

"Breast screening tests through true isotropic 3D imaging technology can help detect breast cancer at an early stage by ensuring the chances of higher survival rates."

Unlike other screening methods, Koning Vera Breast CT (KBCT) offers a non-radiological and non-invasive screening approach to breast cancer detection. By analysing CTCs, KBCT provides a more accurate and comprehensive screening test. The test is based on functional enrichment of breast-adenocarcinoma-associated CTCs (Circulating tumour cells) and their identification using multiplexed fluorescence immunocytochemistry (ICC)/(mIHC)/multiplex immunofluorescence (mIF) profiling. This profiling like GCDFP15, GATA3, EpCAM, PanCK, and CD45 further enhances the accuracy of the screening.

But why is early detection so crucial in breast cancer? Well, it's simple – the earlier breast cancer is detected, the higher the chances of survival. 

By identifying breast cancer at its earliest stages, when the tumour is small and hasn't spread, treatment options and outcomes are significantly improved. That's why technologies like Koning Vera Breast CT (KBCT) have the potential to save lives and make a real difference in the fight against breast cancer.

How Common is Breast Cancer?

  • Breast cancer claimed the lives of 670,000 individuals worldwide in 2022 out of 2.3 million women diagnosed with Breast cancer.    
  • Surprisingly, half of all breast cancer cases occur in women with no identifiable risk factors except age and gender.  
  • Did you know that breast cancer was the most prevalent cancer among women in 157 out of 185 countries in 2022?  
  • Breast cancer knows no borders, affecting individuals in every country across the globe.  
  • Men are not exempt from breast cancer, with approximately 0.5–1% of cases occurring in males.  
  • In the U.S., breast cancer reigns as the most frequently diagnosed cancer in women, accounting for 30% of new diagnoses annually.  
  • Shockingly, 13% of American women are projected to develop invasive breast cancer in their lifetime.  
  • By 2023, approximately 297,790 new cases of invasive breast cancer will be diagnosed in women in the United States. This highlights the ongoing need for awareness and support. 
  • Remember, breast cancer can also affect men, with an estimated 2,800 new cases of invasive breast cancer expected in men next year.  
  • Your contribution matters! Support Breastcancer.org to provide vital resources and programs for those impacted by breast cancer. 

What is a screening 3D mammogram?

A 3D mammogram, which is also known as breast tomosynthesis, is an advanced medical screening procedure that uses multiple X-rays to create a 3D image of the breast by covering a detailed image of dense breast tissue. This procedure can be used for both screening and diagnosis of breast cancer. It is a useful diagnostic instrument for early breast cancer detection and reduces the need for additional tests.

During a 3D mammogram, an X-ray arm moves in an arc over the breast, taking multiple low-dose projection images of the compressed breast tissue from different angles. This provides a third dimension to the mammogram, making it easier to detect abnormal tissue growth in the breast. These images are then processed by a computer to create a 3D image. The procedure takes 11 images in less than 7 seconds and is similar to a 2D digital mammogram. 

 


3D mammograms are a type of breast cancer screening diagnostic instrument that is suitable for people over 40 ages with an average risk of cancer. These mammograms can also be used as a diagnostic procedure if you are experiencing breast cancer symptoms, such as breast pain, a lump in your breast, or changes in the appearance of your skin.

When is a breast cancer screening test required?

Women with common symptoms

  • For women aged between 50 to 74 years who have an average risk of breast cancer, the U.S. Preventive Services Task Force (USPSTF) advises getting a 3D mammogram every 2 years.
  •  For women aged between 40 to 49 years, it is advised to consult with a doctor or healthcare provider to determine the appropriate time and frequency of getting mammograms. 
  • For women who are at average risk, it is recommended to have a mammogram every year starting at the age of 40. 
  • Additionally, it is suggested to have a clinical breast exam at least every three years starting at age 20, and every year starting at age 40.

Women at increased risk

  • If you are at an increased risk of breast cancer, it is important to discuss with your doctor the appropriate screening tests and when to start screening.
  •  You may need to undergo 3D mammogram screening at an earlier age and more frequently than women who are at an average risk.

Men might face the risk

  • If you are a man with an inherited BRCA1 or BRCA2 gene mutation, it is recommended to undergo a specialised 3D mammogram screening test for breast cancer and other related cancers.

Transgender people might face the risk

If you are transgender, breast cancer 3D mammogram screening recommendations must be prioritised based on age variations, biological sex, to minimise chances of breast cancer, and other factors.

Who needs breast 3D mammogram screening?

The NHS Breast Screening Programme invites all women aged 50 to 70 to register with their GP for screening every three years. This means that some women may receive their first screening mammogram when they are 52 or 53 years old. Who is eligible for this screening?

  • If you are aged 70>
  • In England, Wales and Northern Ireland, you are no longer automatically invited for screening every 3 years. To continue to have screening, you must contact your GP or local breast screening unit.
  • In Scotland, women can continue to have breast screening until they are 75 years old. However, they won’t automatically be invited and have to contact their local breast screening service.

Let's walk through it.

You've made the important decision to prioritise your health and schedule a screening 3D mammogram. You've done your research, and prepared yourself mentally, but what can you expect on the actual day of your mammogram? 

First things first, a screening mammogram typically takes around 15 minutes. It may not be the most glamorous experience, but it's a straightforward and necessary one. To make the process smoother, it's advisable to wear a shirt that you can easily remove. This ensures convenience and ease during the exam.

But here's an important tip: 

Avoid using deodorant, perfume, powder, or lotion under your arms or on your breasts before your mammogram. These seemingly harmless products can show up on the mammogram images and make it difficult for the radiologist to interpret the results accurately. So, it's best to go au naturel on the day of your screening.

Is screening mammograms painful? 

Now, the answer is no! While you may experience some pressure or discomfort, it's generally not a painful procedure. However, it's essential to communicate with the technologist conducting the mammogram. If you have any concerns or feel discomfort during the test, don't hesitate to let them know. They are present to guarantee your comfort and are available to answer any questions you may have.

Now come for how much waiting time – what about the results?

 Within two weeks, you should receive the results of your screening 3D mammogram report from the imaging centre or your doctor. If you haven't heard anything after this timeframe, don't panic. Simply give your doctor a call to check on the progress. Remember, it's better to be proactive and stay informed.

But what can the 3D mammogram going to reveal? 

Well, there are a few possible findings. One scenario is the best-case scenario: the mammogram may show no signs of breast cancer. This is a huge relief and a reason to celebrate. Another possibility is that it may show a benign (not cancerous) condition. While it can still be a cause for concern, the likelihood of it being cancerous is significantly reduced.

Lastly, there is a chance that an abnormal finding, such as calcifications build up in breast tissue, may appear on your mammogram. This doesn't immediately imply a cancer diagnosis, but it does require further investigation and follow-up tests to rule out any potential concerns. Remember, early detection is key, and additional tests will provide a clearer picture of your breast health.

So, there you have it. A screening mammogram is a relatively quick and painless procedure that plays a vital role in maintaining your breast health. By following these guidelines, communicating with your healthcare professionals, and staying proactive about your results, you're taking a proactive step towards prioritizing your well-being. Stay vigilant, stay informed, and be proud of taking this important step in caring for yourself.

So, whether you're due for your first screening 3D mammogram or have concerns about follow-up tests after an abnormal finding, understanding the importance of early breast cancer detection and the advancements in screening tests can empower you to take control of your health. Explore the breast health screening possibilities that Koning Vera Breast CT (KBCT) offers and remember that early detection is the key to a healthier future.

Order Euronoxx Medical's Koning Vera Breast CT (KBCT) for your UK hospitals, across NHS, and UK clinics. Our top-notch diagnostic instruments, hospital equipment and surgical instruments are at your service.

 


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